| MLS 2022 | ||||
| 1ª Semana | ||||
| 26-feb-2022 | Chester | Union | 1 | Burke |
| Minnesota United | 1 | Lod | ||
| 26-feb-2022 | Columbus | Crew | 4 | Berry, Etienne, Diaz, Zelarayan |
| Whitecaps | 0 | |||
| 26-feb-2022 | Los Angeles | Los Angeles | 3 | Vela (3, 1P) |
| Rapids | 0 | |||
| 26-feb-2022 | Frisco | Dallas | 1 | Obrian |
| Toronto | 1 | Osorio | ||
| 26-feb-2022 | Washington | DC United | 3 | Estrada (2, 1P), Kamara |
| Charlotte | 0 | |||
| 26-feb-2022 | Austin | Austin | 5 | Dominguez (2), Ring, Driussi, Kann (A) |
| Cincinnati | 0 | |||
| 26-feb-2022 | Fort Lauderdale | Inter | 0 | |
| Fire | 0 | |||
| 26-feb-2022 | San Jose | Earthquakes | 1 | Lopez |
| Red Bulls | 3 | Klimala, Fernandez, Barlow | ||
| 26-feb-2022 | Portland | Timbers | 2 | Asprilla, Chara |
| Revolution | 2 | Bye, Lletget | ||
| 27-feb-2022 | Orlando | Orlando City | 2 | Alexandre Pato, Michel |
| Impact | 0 | |||
| 27-feb-2022 | Atlanta | Atlanta United | 3 | Luiz Araujo, Dwyer, Wiley |
| Sporting | 1 | Salloi | ||
| 27-feb-2022 | Carson | Galaxy | 1 | Hernandez |
| New York City | 0 | |||
| 27-feb-2022 | Houston | Dynamo | 0 | |
| Real Salt Lake | 0 | |||
| 27-feb-2022 | Seattle | Sounders | 0 | |
| Nashville | 1 | Godoy | ||
| 2ª Semana | ||||
| 5-mar-2022 | Foxborough | Revolution | 1 | Gil (P) |
| Dallas | 0 | |||
| 5-mar-2022 | Toronto | Toronto | 1 | Jimenez |
| Red Bulls | 4 | Morgan (3), Long | ||
| 5-mar-2022 | Kansas City | Sporting | 1 | Walter |
| Dynamo | 0 | |||
| 5-mar-2022 | Montreal | Impact | 1 | Lappalainen |
| Union | 2 | Bedoya, Gazdag | ||
| 5-mar-2022 | San Jose | Earthquakes | 3 | Espinoza (P), Calvo (2) |
| Crew | 3 | Zelarayan (2), Zardes | ||
| 5-mar-2022 | Cincinnati | Cincinnati | 0 | |
| DC United | 1 | Kamara (P) | ||
| 5-mar-2022 | Bridgeview | Fire | 0 | |
| Orlando City | 0 | |||
| 5-mar-2022 | Saint Paul | Minnesota United | 1 | Dotson |
| Nashville | 1 | Sapong | ||
| 5-mar-2022 | Commerce City | Rapids | 3 | Rubio, Lewis, Shinyashiki |
| Atlanta United | 0 | |||
| 5-mar-2022 | Sandy | Real Salt Lake | 1 | Wood |
| Sounders | 0 | |||
| 5-mar-2022 | Vancouver | Whitecaps | 0 | |
| New York City | 0 | |||
| 5-mar-2022 | Charlotte | Charlotte | 0 | |
| Galaxy | 1 | Alvarez | ||
| 6-mar-2022 | Austin | Austin | 5 | Driussi (2), Cascante, Finlay (2) |
| Inter | 1 | Campana | ||
| 7-mar-2022 | Los Angeles | Los Angeles | 1 | Fall |
| Timbers | 1 | Chara | ||
| 3ª Semana | ||||
| 12-mar-2022 | Bronx | New York City | 4 | Callens, Rodriguez, Talles Magno, Thiago Andrade |
| Impact | 1 | Brault-Guillard | ||
| 12-mar-2022 | Columbus | Crew | 2 | Zelarayan, Etienne |
| Toronto | 1 | Jimenez | ||
| 12-mar-2022 | Fort Lauderdale | Inter | 0 | |
| Los Angeles | 2 | Opoku, Tajouri | ||
| 12-mar-2022 | Seattle | Sounders | 3 | Morris, Montero (P), Arreaga |
| Galaxy | 2 | Hernandez, Douglas Costa | ||
| 12-mar-2022 | Houston | Dynamo | 2 | Quintero (2) |
| Whitecaps | 1 | Cavallini | ||
| 12-mar-2022 | Washington | DC United | 0 | |
| Fire | 2 | Ivanov, Bornstein | ||
| 12-mar-2022 | Foxborough | Revolution | 2 | Boateng, Altidore |
| Real Salt Lake | 3 | Cordova, Glad, Schmitt | ||
| 12-mar-2022 | Orlando | Orlando City | 1 | Junior Urso |
| Cincinnati | 2 | Vazquez (2) | ||
| 12-mar-2022 | Chester | Union | 2 | Burke, Gazdag (P) |
| Earthquakes | 0 | |||
| 12-mar-2022 | Frisco | Dallas | 2 | Jara (P), Velasco |
| Nashville | 0 | |||
| 12-mar-2022 | Commerce City | Rapids | 2 | Rubio, Kaye |
| Sporting | 0 | |||
| 13-mar-2022 | Portland | Timbers | 1 | Tuiloma |
| Austin | 0 | |||
| 13-mar-2022 | Atlanta | Atlanta United | 2 | Martinez (P), Mulraney |
| Charlotte | 1 | Armour | ||
| 13-mar-2022 | Harrison | Red Bulls | 0 | |
| Minnesota United | 1 | Amarilla | ||
| 4ª Semana | ||||
| 19-mar-2022 | Cincinnati | Cincinnati | 3 | Matarrita, Vazquez (2) |
| Inter | 1 | Higuain (P) | ||
| 19-mar-2022 | Bronx | New York City | 0 | |
| Union | 2 | Bedoya, Gazdag | ||
| 19-mar-2022 | Toronto | Toronto | 2 | Pozuelo, Osorio |
| DC United | 1 | Canouse | ||
| 19-mar-2022 | Carson | Galaxy | 0 | |
| Orlando City | 1 | Torres | ||
| 19-mar-2022 | Atlanta | Atlanta United | 3 | Martinez, Almada, Lennon |
| Impact | 3 | Mihailovic, Kone, Quioto (P) | ||
| 19-mar-2022 | Bridgeview | Fire | 3 | Przybylko (2), Shaqiri (P) |
| Sporting | 1 | Espinoza | ||
| 19-mar-2022 | Charlotte | Charlotte | 3 | Swiderski (2), Bender |
| Revolution | 1 | Gil (P) | ||
| 19-mar-2022 | Saint Paul | Minnesota United | 1 | Amarilla |
| Earthquakes | 0 | |||
| 19-mar-2022 | Houston | Dynamo | 1 | Pasher |
| Rapids | 1 | Kaye | ||
| 19-mar-2022 | Frisco | Dallas | 4 | Ferreira (3), Arriola |
| Timbers | 1 | Niezgoda | ||
| 19-mar-2022 | Sandy | Real Salt Lake | 2 | Wood, Schmitt |
| Nashville | 1 | Zimmerman | ||
| 20-mar-2022 | Harrison | Red Bulls | 1 | Barlow |
| Crew | 1 | Nagbe | ||
| 20-mar-2022 | Austin | Austin | 1 | Fagundez |
| Sounders | 1 | Bruin | ||
| 20-mar-2022 | Los Angeles | Los Angeles | 3 | Hollingshead (2), Vela |
| Whitecaps | 1 | Blackman | ||
| 5ª Semana | ||||
| 26-mar-2022 | Charlotte | Charlotte | 2 | Swiderski (2) |
| Cincinnati | 0 | |||
| 26-mar-2022 | Kansas City | Sporting | 1 | Russell |
| Real Salt Lake | 0 | |||
| 27-mar-2022 | Portland | Timbers | 1 | Paredes (P) |
| Orlando City | 1 | Junior Urso | ||
| 6ª Semana | ||||
| 2-abr-2022 | Bridgeview | Fire | 0 | |
| Dallas | 0 | |||
| 2-abr-2022 | Cincinnati | Cincinnati | 3 | Vazquez, Johnston (A), Acosta (P) |
| Impact | 4 | Mihailovic (2), Kamara, Torres | ||
| 2-abr-2022 | Toronto | Toronto | 2 | Jimenez, Martins (A) |
| New York City | 1 | Heber | ||
| 2-abr-2022 | Columbus | Crew | 0 | |
| Nashville | 1 | Muyl | ||
| 2-abr-2022 | Washington | DC United | 0 | |
| Atlanta United | 1 | Moreno | ||
| 2-abr-2022 | Foxborough | Revolution | 0 | |
| Red Bulls | 1 | Polster (A) | ||
| 2-abr-2022 | Orlando | Orlando City | 2 | Alexandre Pato, Joao Moutinho |
| Los Angeles | 4 | Rodriguez, Murillo, Ilie, Opoku | ||
| 2-abr-2022 | Chester | Union | 2 | Carranza, Gazdag |
| Charlotte | 0 | |||
| 2-abr-2022 | San Jose | Earthquakes | 2 | Ebobisse (P), Cowell |
| Austin | 2 | Urruti, Driussi (P) | ||
| 2-abr-2022 | Saint Paul | Minnesota United | 1 | Reynoso (P) |
| Sounders | 2 | Joao Paulo, Kallman (A) | ||
| 2-abr-2022 | Vancouver | Whitecaps | 1 | Raposo |
| Sporting | 0 | |||
| 2-abr-2022 | Commerce City | Rapids | 1 | Abubakar |
| Real Salt Lake | 1 | Ruiz (P) | ||
| 2-jul-2022 | Fort Lauderdale | Inter | 1 | Higuain (P) |
| Dynamo | 3 | Quintero, Picault (2, 1P) | ||
| 3-jul-2022 | Portland | Timbers | 1 | Tuiloma |
| Galaxy | 3 | Hernandez (2), Tuiloma (A) | ||
| 7ª Semana | ||||
| 9-abr-2022 | Orlando | Orlando City | 1 | Kara |
| Fire | 0 | |||
| 9-abr-2022 | Fort Lauderdale | Inter | 3 | Campana (3) |
| Revolution | 2 | Rennicks, Gil (P) | ||
| 9-abr-2022 | Harrison | Red Bulls | 1 | Fernandez |
| Montreal | 2 | Camacho, Quioto | ||
| 9-abr-2022 | Chester | Union | 1 | Room (A) |
| Crew | 0 | |||
| 9-abr-2022 | Carson | Galaxy | 2 | Hernandez, Coulibaly |
| Los Angeles | 1 | Arango | ||
| 9-abr-2022 | Sandy | Real Salt Lake | 2 | Meram, Kreilach |
| Toronto | 2 | Thompson, Nelson | ||
| 9-abr-2022 | Frisco | Dallas | 3 | Servania, Ferreira (2) |
| Rapids | 1 | Rubio | ||
| 9-abr-2022 | Houston | Dynamo | 4 | Ferreira (2), Quintero, Hadebe |
| Earthquakes | 3 | Ebobisse (2), Thompson | ||
| 9-abr-2022 | Kansas City | Sporting | 1 | Walter |
| Nashville | 2 | Romney, Sapong | ||
| 9-abr-2022 | Vancouver | Whitecaps | 2 | Dajome, Gauld (P) |
| Timbers | 3 | Asprilla (P), Niezgoda, Chara | ||
| 10-abr-2022 | Charlotte | Charlotte | 1 | Alcivar |
| Atlanta United | 0 | |||
| 10-abr-2022 | Austin | Austin | 1 | Urruti |
| Minnesota United | 0 | |||
| 8ª Semana | ||||
| 16-abr-2022 | Montreal | Impact | 2 | Mihailovic, Quioto |
| Whitecaps | 1 | White | ||
| 16-abr-2022 | San Jose | Earthquakes | 2 | Ebobisse (2) |
| Nashville | 2 | Mukhtar (2) | ||
| 16-abr-2022 | Atlanta | Atlanta United | 0 | |
| Cincinnati | 0 | |||
| 16-abr-2022 | Houston | Dynamo | 0 | |
| Timbers | 0 | |||
| 16-abr-2022 | Harrison | Red Bulls | 0 | |
| Dallas | 0 | |||
| 16-abr-2022 | Columbus | Crew | 0 | |
| Orlando City | 2 | Schlegel, Kara | ||
| 16-abr-2022 | Foxborough | Revolution | 2 | Buksa, Polster |
| Charlotte | 1 | Ortiz | ||
| 16-abr-2022 | Toronto | Toronto | 2 | Jimenez, Pozuelo |
| Union | 1 | Carranza | ||
| 16-abr-2022 | Bridgeview | Fire | 0 | |
| Galaxy | 0 | |||
| 16-abr-2022 | Washington | DC United | 2 | Kamara (2) |
| Austin | 3 | Hoesen, Driussi, Gabrielsen | ||
| 16-abr-2022 | Saint Paul | Minnesota United | 3 | Dibassy, Lod, Danladi |
| Rapids | 1 | Rubio | ||
| 16-abr-2022 | Seattle | Sounders | 0 | |
| Inter | 1 | Robinson | ||
| 17-abr-2022 | Bronx | New York City | 6 | Castellanos (4, 2P), Thiago Andrade (2) |
| Real Salt Lake | 0 | |||
| 17-abr-2022 | Los Angeles | Los Angeles | 3 | Arango, Tajouri, Cifuentes |
| Sporting | 1 | Palacios (A) | ||
| 9ª Semana | ||||
| 23-abr-2022 | Frisco | Dallas | 2 | Ntsabeleng, Quignon |
| Dynamo | 1 | Ferreira | ||
| 23-abr-2022 | Chester | Union | 1 | Carranza (P) |
| Impact | 1 | Kamara | ||
| 23-abr-2022 | Saint Paul | Minnesota United | 3 | Reynoso, Arriaga, Lod |
| Fire | 0 | |||
| 23-abr-2022 | Washington | DC United | 3 | Fountas (2), Estrada |
| Revolution | 2 | Bye, Buksa | ||
| 23-jul-2022 | Austin | Austin | 3 | Urruti (2), Driussi |
| Whitecaps | 0 | |||
| 23-abr-2022 | Kansas City | Sporting | 0 | |
| Crew | 0 | |||
| 23-abr-2022 | Commerce City | Rapids | 0 | |
| Charlotte | 0 | |||
| 23-abr-2022 | Portland | Timbers | 0 | |
| Real Salt Lake | 0 | |||
| 23-abr-2022 | San Jose | Earthquakes | 4 | Espinoza (3, 1P), Yueill |
| Sounders | 3 | Lodeiro (P), Roldan, Morris | ||
| 23-abr-2022 | Carson | Galaxy | 1 | Joveljic |
| Nashville | 0 | |||
| 24-abr-2022 | Fort Lauderdale | Inter | 2 | Campana, Duke |
| Atlanta United | 1 | Cisneros | ||
| 24-abr-2022 | Orlando | Orlando City | 0 | |
| Red Bulls | 3 | Luquinhas, Casseres, Morgan (P) | ||
| 24-abr-2022 | Cincinnati | Cincinnati | 1 | L. Acosta |
| Los Angeles | 2 | K. Acosta, Musovski | ||
| 24-abr-2022 | Bronx | New York City | 5 | Castellanos, Andrade, Rodriguez, Parks, Pereira |
| Toronto | 4 | Jimenez (2), Kerr, Bradley | ||
| 10ª Semana | ||||
| 30-abr-2022 | Houston | Dynamo | 1 | Ferreira |
| Austin | 2 | Daniel Pereira, Driussi | ||
| 30-abr-2022 | Toronto | Toronto | 1 | Jimenez |
| Cincinnati | 2 | Murphy, Acosta | ||
| 30-abr-2022 | Sandy | Real Salt Lake | 1 | Silva |
| Galaxy | 0 | |||
| 30-abr-2022 | Montreal | Impact | 2 | Miller, Torres |
| Atlanta United | 1 | Moreno | ||
| 30-abr-2022 | Columbus | Crew | 3 | Pedro Santos, Etienne, Nagbe |
| DC United | 0 | |||
| 30-abr-2022 | Foxborough | Revolution | 2 | Rivera, Buksa |
| Inter | 0 | |||
| 30-abr-2022 | Orlando | Orlando City | 2 | Ruan, Torres |
| Charlotte | 1 | Fuchs (P) | ||
| 30-abr-2022 | Bridgeview | Fire | 0 | Shaqiri (P) |
| Red Bulls | 2 | Klimala (2, 1P) | ||
| 30-abr-2022 | Kansas City | Sporting | 2 | Russell (P), Salloi |
| Dallas | 2 | Velasco, Ferreira | ||
| 30-abr-2022 | Commerce City | Rapids | 2 | Rubio, Kaye |
| Timbers | 0 | |||
| 1-may-2022 | Bronx | New York City | 3 | Parks, Gabriel Pereira, Gloster |
| Earthquakes | 0 | |||
| 1-may-2022 | Nashville | Nashville | 1 | Leal (P) |
| Union | 1 | Uhre | ||
| 1-may-2022 | Los Angeles | Los Angeles | 2 | Hollingshead, Cifuentes |
| Minnesota United | 0 | |||
| 11ª Semana | ||||
| 4-may-2022 | Cincinnati | Cincinnati | 2 | Harris, Acosta (P) |
| Toronto | 0 | |||
| 7-may-2022 | Charlotte | Charlotte | 1 | Shinyashiki |
| Inter | 0 | |||
| 7-may-2022 | Montreal | Montreal | 4 | Waterman, Mihailovic, Torres, Brault-Guillard |
| Orlando City | 1 | Joao Moutinho | ||
| 7-may-2022 | Atlanta | Atlanta United | 4 | Cisneros (3), Lennon |
| Fire | 1 | Offor | ||
| 7-may-2022 | Harrison | Red Bulls | 1 | Long |
| Timbers | 1 | Niezgoda | ||
| 7-may-2022 | Bronx | New York City | 0 | |
| Sporting | 0 | |||
| 7-may-2022 | Washington | DC United | 2 | Fountas (2) |
| Dynamo | 0 | |||
| 7-may-2022 | Foxborough | Revolution | 2 | Jones, Buksa |
| Crew | 2 | Berry, Hurtado | ||
| 7-may-2022 | Saint Paul | Minnesota United | 0 | |
| Cincinnati | 1 | Vazquez | ||
| 7-may-2022 | Frisco | Dallas | 2 | Ferreira, Arriola |
| Sounders | 0 | |||
| 7-may-2022 | San Jose | Earthquakes | 1 | Nathan |
| Rapids | 0 | |||
| 7-may-2022 | Los Angeles | Los Angeles | 2 | Opoku, Escobar |
| Union | 2 | Gazdag, Carranza | ||
| 8-may-2022 | Vancouver | Whitecaps | 1 | Ricketts |
| Toronto | 0 | |||
| 8-may-2022 | Nashville | Nashville | 2 | Romney, Sapong |
| Real Salt Lake | 0 | |||
| 8-may-2022 | Austin | Austin | 0 | |
| Galaxy | 1 | Delgado | ||
| 12ª Semana | ||||
| 14-may-2022 | Toronto | Toronto | 0 | |
| Orlando City | 1 | Smith | ||
| 14-may-2022 | Commerce City | Rapids | 2 | Zardes (P), Rubio (P) |
| Los Angeles | 0 | |||
| 14-may-2022 | Charlotte | Charlotte | 0 | |
| Impact | 2 | Mihailovic, Johnston | ||
| 14-may-2022 | Bronx | New York City | 2 | Talles Magno, Castellanos |
| Crew | 0 | |||
| 14-may-2022 | Vancouver | Whitecaps | 3 | Cavallini, Raposo, Godoy |
| Earthquakes | 3 | Monteiro, Ebobisse (2) | ||
| 14-may-2022 | Chester | Union | 1 | Gazdag |
| Red Bulls | 1 | Luquinhas | ||
| 14-may-2022 | Bridgeview | Fire | 1 | Duran |
| Cincinnati | 2 | Czichos (A), Acosta | ||
| 14-may-2022 | Houston | Dynamo | 2 | Carrasquilla, Quintero (P) |
| Nashville | 0 | |||
| 14-may-2022 | Fort Lauderdale | Inter | 2 | Campana, Lowe |
| DC United | 2 | Fountas, Kamara | ||
| 14-may-2022 | Sandy | Real Salt Lake | 2 | Chang, Brody |
| Austin | 1 | Ring | ||
| 14-may-2022 | Portland | Timbers | 7 | Tuiloma, Blanco (2), Fogaça (2), Loria, Moreno |
| Sporting | 2 | Russell, Tzionis | ||
| 14-may-2022 | Carson | Galaxy | 1 | Douglas Costa |
| Dallas | 3 | Ferreira (2), Arriola | ||
| 15-may-2022 | Atlanta | Atlanta United | 2 | Almada, Luiz Araujo |
| Revolution | 2 | Buksa (2) | ||
| 15-may-2022 | Seattle | Sounders | 3 | Ruidiaz (P), Roldan, Lodeiro |
| Minnesota United | 1 | Lod | ||
| 13ª Semana | ||||
| 18-may-2022 | Washington | DC United | 0 | |
| New York City | 2 | Callens, Castellanos (P) | ||
| 18-may-2022 | Harrison | Red Bulls | 3 | Morgan (P), Harper, Klimala |
| Fire | 3 | Mueller, Omsberg, Shaqiri | ||
| 18-may-2022 | Chester | Union | 0 | |
| Inter | 0 | |||
| 18-may-2022 | Saint Paul | Minnesota United | 1 | Lod |
| Galaxy | 1 | Kljestan (P) | ||
| 18-may-2022 | Houston | Dynamo | 0 | |
| Sounders | 1 | Ruidiaz | ||
| 18-may-2022 | Kansas City | Sporting | 2 | Salloi (2) |
| Rapids | 1 | Lucas Esteves | ||
| 18-may-2022 | Nashville | Nashville | 2 | Muyl, Mukhtar |
| Impact | 1 | Kamara | ||
| 18-may-2022 | Vancouver | Whitecaps | 2 | White, Cavallini (P) |
| Dallas | 1 | Arriola | ||
| 18-may-2022 | Los Angeles | Los Angeles | 1 | Vela (P) |
| Austin | 2 | Gabrielsen, Fagundez | ||
| 18-may-2022 | San Jose | Earthquakes | 3 | Yueill, Monteiro (2) |
| Timbers | 2 | Paredes, Tuiloma | ||
| 21-may-2022 | Columbus | Crew | 0 | |
| Los Angeles | 2 | Vela, Cifuentes | ||
| 21-may-2022 | Washington | DC United | 2 | Flores, Estrada |
| Toronto | 2 | Akinola, Osorio | ||
| 21-may-2022 | Cincinnati | Cincinnati | 2 | Vazquez, Barreal |
| Revolution | 3 | Lletget, Buksa, McNamara | ||
| 21-may-2022 | Nashville | Nashville | 2 | Sapong, Mukhtar |
| Atlanta United | 2 | Almada, Dwyer | ||
| 22-may-2022 | Montreal | Impact | 1 | Mihailovic |
| Real Salt Lake | 2 | Glad, Cordova | ||
| 22-may-2022 | Charlotte | Charlotte | 2 | Shinyashiki, Rios |
| Whitecaps | 1 | Ricketts | ||
| 22-may-2022 | Bronx | New York City | 1 | Heber (P) |
| Fire | 0 | |||
| 22-may-2022 | Fort Lauderdale | Inter | 2 | Lassiter, Taylor |
| Red Bulls | 0 | |||
| 22-may-2022 | Frisco | Dallas | 1 | Arriola |
| Minnesota United | 2 | Lod, Taylor | ||
| 22-may-2022 | San Jose | Earthquakes | 1 | Yueill |
| Sporting | 1 | Russell | ||
| 22-may-2022 | Austin | Austin | 2 | Driussi (P), Djitte |
| Orlando City | 2 | Kara, Ruan | ||
| 22-may-2022 | Commerce City | Rapids | 1 | Lewis |
| Sounders | 0 | |||
| 22-may-2022 | Carson | Galaxy | 0 | |
| Dynamo | 3 | Ferreira, Pasher, Ulfarsson | ||
| 22-may-2022 | Portland | Timbers | 0 | |
| Union | 2 | Gazdag, Sergio Santos | ||
| 14ª Semana | ||||
| 28-may-2022 | Los Angeles | Los Angeles | 3 | Arango (P), Hollingshead, Rodriguez |
| Earthquakes | 2 | Ebobisse (2) | ||
| 28-may-2022 | Atlanta | Atlanta United | 1 | Dwyer |
| Crew | 2 | Mensah, Hurtado | ||
| 28-may-2022 | Harrison | Red Bulls | 4 | Luquinhas (2), Morgan, Alfaro (A) |
| DC United | 1 | Kamara | ||
| 28-may-2022 | Toronto | Toronto | 3 | Kerr, Pozuelo (2, 1P) |
| Fire | 2 | Teran, Przybylko | ||
| 28-may-2022 | Montreal | Impact | 4 | Waterman, Quioto (2, 1P), Choiniere |
| Cincinnati | 3 | Moreno (2), Barreal | ||
| 28-may-2022 | Foxborough | Revolution | 1 | Bou (P) |
| Union | 1 | Uhre | ||
| 28-may-2022 | Orlando | Orlando City | 1 | Kara |
| Dallas | 3 | Arriola (2), Jara | ||
| 28-may-2022 | Fort Lauderdale | Inter | 2 | Campana, Taylor |
| Timbers | 1 | Tuiloma | ||
| 28-may-2022 | Saint Paul | Minnesota United | 0 | |
| New York City | 1 | Callens | ||
| 28-may-2022 | Commerce City | Rapids | 1 | Rubio |
| Nashville | 3 | Sapong, Mukhtar (2) | ||
| 28-may-2022 | Kansas City | Sporting | 0 | |
| Whitecaps | 1 | Cavallini (P) | ||
| 28-may-2022 | Sandy | Real Salt Lake | 3 | Wood, Cordova, Glad |
| Dynamo | 0 | |||
| 29-may-2022 | Carson | Galaxy | 4 | Hernandez, Joveljic (2), Alvarez |
| Austin | 1 | Fagundez | ||
| 29-may-2022 | Seattle | Sounders | 2 | Morris, Ruidiaz |
| Charlotte | 1 | Bender | ||
| 15ª Semana | ||||
| 4-jun-2022 | Vancouver | Whitecaps | 2 | Veselinovic, Gauld (P) |
| Real Salt Lake | 1 | Meram | ||
| 16ª Semana | ||||
| 11-jun-2022 | Charlotte | Charlotte | 2 | Bender, Jones |
| Red Bulls | 0 | |||
| 11-jun-2022 | Nashville | Nashville | 0 | |
| Earthquakes | 0 | |||
| 12-jun-2022 | Kansas City | Sporting | 1 | Russell |
| Revolution | 2 | Bou, Boateng | ||
| 17ª Semana | ||||
| 14-jun-2022 | Seattle | Sounders | 4 | Lodeiro (P), Ruidiaz (2), Roldan |
| Whitecaps | 0 | |||
| 15-jun-2022 | Foxborough | Revolution | 1 | Gil |
| Orlando City | 1 | Jansson | ||
| 18-jun-2022 | Seattle | Sounders | 1 | Rusnak |
| Los Angeles | 1 | Arango | ||
| 18-jun-2022 | Carson | Galaxy | 1 | Joveljic |
| Timbers | 1 | Chara | ||
| 18-jun-2022 | Harrison | Red Bulls | 2 | Morgan, Luquinhas |
| Toronto | 0 | |||
| 18-jun-2022 | Columbus | Crew | 1 | Hurtado |
| Charlotte | 1 | Shinyashiki | ||
| 18-jun-2022 | Montreal | Impact | 0 | |
| Austin | 1 | Urruti | ||
| 18-jun-2022 | Orlando | Orlando City | 2 | Kara (2) |
| Dynamo | 1 | Ferreira | ||
| 18-jun-2022 | Chester | Union | 1 | Bedoya |
| Cincinnati | 1 | Vazquez | ||
| 18-jun-2022 | Bridgeview | Fire | 1 | Herbers |
| DC United | 0 | |||
| 18-jun-2022 | Frisco | Dallas | 0 | |
| Whitecaps | 2 | Cavallini, Caicedo | ||
| 18-jun-2022 | Sandy | Real Salt Lake | 2 | Silva, Savarino |
| Earthquakes | 0 | |||
| 19-jun-2022 | Atlanta | Atlanta United | 2 | Luiz Araujo, Martinez |
| Inter | 0 | |||
| 19-jun-2022 | Foxborough | Revolution | 2 | Borrero, Bou |
| Minnesota United | 1 | Reynoso (P) | ||
| 19-jun-2022 | Bronx | New York City | 1 | Talles Magno |
| Rapids | 1 | Barrios | ||
| 19-jun-2022 | Nashville | Nashville | 1 | Loba |
| Sporting | 2 | Hernandez, Zusi | ||
| 18ª Semana | ||||
| 24-jun-2022 | Cincinnati | Cincinnati | 1 | Brenner |
| Orlando City | 0 | |||
| 25-jun-2022 | Seattle | Sounders | 3 | Bruin, Morris, Roldan |
| Sporting | 0 | |||
| 25-jun-2022 | Washington | DC United | 1 | Fountas |
| Nashville | 3 | Lovitz, Mukhtar (2) | ||
| 25-jun-2022 | Montreal | Impact | 2 | Quioto, Choiniere |
| Charlotte | 1 | Corujo | ||
| 25-jun-2022 | Toronto | Toronto | 2 | Osorio, Priso-Mbongue |
| Atlanta United | 1 | Luiz Araujo | ||
| 25-jun-2022 | Houston | Dynamo | 2 | Ulfarsson, Quintero |
| Fire | 0 | |||
| 25-jun-2022 | Fort Lauderdale | Inter | 2 | Vassilev (2) |
| Minnesota United | 1 | Amarilla | ||
| 25-jun-2022 | Austin | Austin | 2 | Driussi, Hoesen |
| Dallas | 2 | Arriola, Servania | ||
| 25-jun-2022 | Sandy | Real Salt Lake | 0 | |
| Crew | 0 | |||
| 25-jun-2022 | Portland | Timbers | 3 | Blanco (P), Niezgoda (2) |
| Rapids | 0 | |||
| 26-jun-2022 | Los Angeles | Los Angeles | 2 | Arango, Palacios |
| Red Bulls | 0 | |||
| 26-jun-2022 | Chester | Union | 2 | Uhre, Burke |
| New York City | 1 | Castellanos (P) | ||
| 26-jun-2022 | Vancouver | Whitecaps | 0 | |
| Revolution | 0 | |||
| 19ª Semana | ||||
| 29-jun-2022 | Cincinnati | Cincinnati | 4 | Acosta, Brenner (3) |
| New York City | 4 | Talles Magno, Heber (2), Gabriel Pereira | ||
| 29-jun-2022 | Toronto | Toronto | 1 | Jimenez |
| Crew | 2 | Zawadski, Nagbe | ||
| 29-jun-2022 | Bridgeview | Fire | 1 | Navarro |
| Union | 0 | |||
| 29-jun-2022 | Seattle | Sounders | 1 | Morris |
| Impact | 2 | Toye (2) | ||
| 29-jun-2022 | Los Angeles | Los Angeles | 3 | Musovski, Arango, Opoku |
| Dallas | 1 | Ferreira | ||
| 29-jun-2022 | Portland | Timbers | 2 | Moreno (2, 1P) |
| Dynamo | 1 | Quintero | ||
| 29-jun-2022 | Carson | Galaxy | 2 | Delgado (P), Joveljic |
| Minnesota United | 3 | Reynoso (2), Fragapane | ||
| 30-jun-2022 | Charlotte | Charlotte | 0 | |
| Austin | 1 | Daniel Pereira | ||
| 30-jun-2022 | Harrison | Red Bulls | 2 | Morgan (P), Ngoma |
| Atlanta United | 1 | Martinez | ||
| 2-jul-2022 | Toronto | Toronto | 0 | |
| Sounders | 2 | Teves, Montero | ||
| 2-jul-2022 | Vancouver | Whitecaps | 1 | Cubas |
| Los Angeles | 0 | |||
| 3-jul-2022 | Bronx | New York City | 2 | Castellanos (2) |
| Atlanta United | 2 | Martinez, Dwyer | ||
| 3-jul-2022 | Columbus | Crew | 0 | |
| Union | 0 | |||
| 3-jul-2022 | Foxborough | Revolution | 2 | Borrero, Bou |
| Cincinnati | 2 | Kessler (A), Brenner | ||
| 3-jul-2022 | Saint Paul | Minnesota United | 3 | Reynoso (2), Amarilla |
| Real Salt Lake | 2 | Savarino, Julio | ||
| 3-jul-2022 | Kansas City | Sporting | 0 | |
| Red Bulls | 1 | Long | ||
| 3-jul-2022 | Houston | Dynamo | 1 | Picault |
| Charlotte | 2 | Vera (A), Shinyashiki | ||
| 3-jul-2022 | Nashville | Nashville | 2 | Davis, Mukhtar |
| Timbers | 2 | Asprilla (P), Niezgoda | ||
| 3-jul-2022 | San Jose | Earthquakes | 2 | Kikanovic (2) |
| Fire | 1 | Gutierrez | ||
| 20ª Semana | ||||
| 4-jul-2022 | Orlando | Orlando City | 3 | Torres, Kara, Alexandre Pato (P) |
| DC United | 5 | Fountas (3), Smith, Robertha | ||
| 4-jul-2022 | Commerce City | Rapids | 2 | Abubakar, Lewis |
| Austin | 3 | Finlay, Driussi, Urruti | ||
| 4-jul-2022 | Frisco | Dallas | 1 | Velasco |
| Inter | 1 | Campana | ||
| 4-jul-2022 | Carson | Galaxy | 4 | Hernandez, Joveljic (P), Raveloson (2) |
| Impact | 0 | |||
| 8-jul-2022 | Chester | Union | 7 | Bedoya (2), Carranza (3), Uhre (2) |
| DC United | 0 | |||
| 8-jul-2022 | Los Angeles | Los Angeles | 3 | Cifuentes (2), Arango |
| Galaxy | 2 | Grandsir, Raveloson | ||
| 8-jul-2022 | Vancouver | Whitecaps | 1 | Cavallini |
| Minnesota United | 3 | Lawrence, Amarilla, Fragapane | ||
| 9-jul-2022 | Bronx | New York City | 4 | Talles Magno (P), Castellanos (2), Gabriel Pereira |
| Revolution | 2 | Bou (2) | ||
| 9-jul-2022 | Seattle | Sounders | 0 | |
| Timbers | 3 | Niezgoda, Moreno (P), Asprilla | ||
| 9-jul-2022 | Atlanta | Atlanta United | 0 | |
| Austin | 3 | Felipe Martins, Finlay, Driussi | ||
| 9-jul-2022 | Charlotte | Charlotte | 4 | Fuchs (P), Swiderski, Ruiz, Shinyashiki |
| Nashville | 1 | Mukhtar (P) | ||
| 9-jul-2022 | Cincinnati | Cincinnati | 1 | Vazquez |
| Red Bulls | 1 | Morgan (P) | ||
| 9-jul-2022 | Montreal | Impact | 1 | Quioto |
| Sporting | 2 | Espinoza, Walter | ||
| 9-jul-2022 | Toronto | Toronto | 2 | Kerr, Osorio |
| Earthquakes | 2 | Ebobisse, Skahan | ||
| 9-jul-2022 | Bridgeview | Fire | 2 | Czichos, Mueller |
| Crew | 3 | Etienne (2), Hernandez | ||
| 9-jul-2022 | Houston | Dynamo | 2 | Ulfarsson, Hadebe |
| Dallas | 2 | Hedges, Ferreira | ||
| 9-jul-2022 | Sandy | Real Salt Lake | 2 | Savarino, Meram |
| Rapids | 2 | Rubio (P), Abubakar | ||
| 9-jul-2022 | Orlando | Orlando City | 1 | Lowe (A) |
| Inter | 0 | |||
| 21ª Semana | ||||
| 12-jul-2022 | Austin | Austin | 3 | Fagundez, Urruti, Ring |
| Dynamo | 1 | Carrasquilla | ||
| 13-jul-2022 | Atlanta | Atlanta United | 2 | Cisneros (2) |
| Real Salt Lake | 1 | Kappelhof | ||
| 13-jul-2022 | Bridgeview | Fire | 2 | Duran (2) |
| Toronto | 0 | |||
| 13-jul-2022 | Cincinnati | Cincinnati | 2 | Barreal, Vazquez |
| Whitecaps | 2 | Gauld, Dajome | ||
| 13-jul-2022 | Washington | DC United | 2 | Fountas, Kamara |
| Crew | 2 | Hernandez (2) | ||
| 13-jul-2022 | Fort Lauderdale | Inter | 1 | Higuain |
| Union | 2 | Gazdag (P), Burke | ||
| 13-jul-2022 | Saint Paul | Minnesota United | 1 | Pulskamp (A) |
| Sporting | 1 | Russell | ||
| 13-jul-2022 | Nashville | Nashville | 1 | Mukhtar |
| Sounders | 0 | |||
| 13-jul-2022 | Commerce City | Rapids | 1 | Zardes |
| Orlando City | 1 | Torres | ||
| 13-jul-2022 | Frisco | Dallas | 0 | |
| New York City | 1 | Heber | ||
| 13-jul-2022 | Carson | Galaxy | 2 | Joveljic (2) |
| Earthquakes | 3 | Espinoza (P), Ebobisse, Lopez | ||
| 16-jul-2022 | Montreal | Impact | 1 | MacNaughton (A) |
| Toronto | 0 | |||
| 16-jul-2022 | Chester | Union | 2 | Uhre, Gazdag (P) |
| Revolution | 1 | Bou | ||
| 16-jul-2022 | Bridgeview | Fire | 1 | Czichos |
| Sounders | 0 | |||
| 16-jul-2022 | Saint Paul | Minnesota United | 2 | Reynoso (2) |
| DC United | 0 | |||
| 16-jul-2022 | Commerce City | Rapids | 2 | Rubio, Zardes |
| Galaxy | 0 | |||
| 16-jul-2022 | Frisco | Dallas | 1 | Arriola |
| Austin | 1 | Fagundez | ||
| 16-jul-2022 | Fort Lauderdale | Inter | 3 | Taylor, Higuain, Rodriguez |
| Charlotte | 2 | Reyna (2) | ||
| 17-jul-2022 | Atlanta | Atlanta United | 1 | Purata |
| Orlando City | 1 | Pereyra | ||
| 17-jul-2022 | Harrison | Red Bulls | 0 | |
| New York City | 1 | Castellanos | ||
| 17-jul-2022 | Columbus | Crew | 2 | Hernandez, Zelarayan (P) |
| Cincinnati | 0 | |||
| 17-jul-2022 | Nashville | Nashville | 1 | Mukhtar (P) |
| Los Angeles | 2 | Arango, Cifuentes | ||
| 17-jul-2022 | Sandy | Real Salt Lake | 3 | Cordova, Ruiz, Savarino |
| Sporting | 0 | |||
| 17-jul-2022 | San Jose | Earthquakes | 1 | Yueill |
| Dynamo | 2 | Ferreira, Ulfarsson | ||
| 17-jul-2022 | Portland | Timbers | 1 | Mora (P) |
| Whitecaps | 1 | White | ||
| 22ª Semana | ||||
| 23-jul-2022 | Bronx | New York City | 2 | Moralez, Heber |
| Inter | 0 | |||
| 23-jul-2022 | Cincinnati | Cincinnati | 1 | Vazquez |
| Nashville | 1 | Bunbury | ||
| 23-jul-2022 | Columbus | Crew | 0 | |
| Revolution | 0 | |||
| 23-jul-2022 | Orlando | Orlando City | 0 | |
| Union | 1 | Gazdag | ||
| 23-jul-2022 | Toronto | Toronto | 4 | Osorio, Bradley (2), Bernardeschi |
| Charlotte | 0 | |||
| 23-jul-2022 | Washington | DC United | 1 | Birnbaum |
| Impact | 2 | Quioto (2) | ||
| 23-jul-2022 | Houston | Dynamo | 1 | Picault |
| Minnesota United | 2 | Fragapane, Hlongwane | ||
| 23-jul-2022 | Kansas City | Sporting | 0 | |
| Los Angeles | 2 | Arango, Bale | ||
| 23-jul-2022 | Sandy | Real Salt Lake | 0 | |
| Dallas | 1 | Ferreira | ||
| 23-jul-2022 | Seattle | Sounders | 2 | Morris, Lodeiro (P) |
| Rapids | 1 | Lewis | ||
| 23-jul-2022 | Vancouver | Whitecaps | 1 | Cavallini |
| Fire | 3 | Shaqiri, Czichos, Mueller | ||
| 23-jul-2022 | Portland | Timbers | 2 | Niezgoda, Asprilla |
| Earthquakes | 1 | Kikanovic | ||
| 24-jul-2022 | Austin | Austin | 3 | Driussi (2), Finlay |
| Red Bulls | 4 | Ngoma, Yearwood, Harper, Barlow | ||
| 24-jul-2022 | Carson | Galaxy | 2 | Cabral, Joveljic |
| Atlanta United | 0 | |||
| 23ª Semana | ||||
| 29-jul-2022 | Los Angeles | Los Angeles | 2 | Opoku, Vela |
| Sounders | 1 | Murillo (A) | ||
| 30-jul-2022 | Saint Paul | Minnesota United | 4 | Fragapane, Hlongwane, Amarilla (2) |
| Timbers | 4 | Blanco (2), Niezgoda, Lawrence (A) | ||
| 30-jul-2022 | Bridgeview | Fire | 0 | |
| Atlanta United | 0 | |||
| 30-jul-2022 | Montreal | Impact | 0 | |
| New York City | 0 | |||
| 30-jul-2022 | Chester | Union | 6 | Gazdag, McGlynn, Uhre (2), Carranza, Sullivan |
| Dynamo | 0 | |||
| 30-jul-2022 | Fort Lauderdale | Inter | 4 | Higuain (3, 1P), Mevey |
| Cincinnati | 4 | Brenner (2), Vazquez (2) | ||
| 30-jul-2022 | Nashville | Nashville | 1 | Bunbury |
| Whitecaps | 1 | Brown | ||
| 30-jul-2022 | Foxborough | Revolution | 0 | |
| Toronto | 0 | |||
| 30-jul-2022 | Kansas City | Sporting | 0 | |
| Austin | 2 | Ring, Driussi | ||
| 30-jul-2022 | Frisco | Dallas | 1 | Jara |
| Galaxy | 0 | |||
| 30-jul-2022 | San Jose | Earthquakes | 2 | Espinoza (P), Ebobisse |
| Real Salt Lake | 2 | Loffelsend, Savarino | ||
| 31-jul-2022 | Washington | DC United | 2 | Durkin, Fountas |
| Orlando City | 1 | Junior Urso | ||
| 24ª Semana | ||||
| 2-ago-2022 | Harrison | Red Bulls | 4 | Yearwood, Long, Morgan (P), Barlow (P) |
| Rapids | 5 | Rubio, Rosenberry, Warner, Barrios, Toure | ||
| 2-ago-2022 | Seattle | Sounders | 1 | Lodeiro (P) |
| Dallas | 0 | |||
| 3-ago-2022 | Charlotte | Charlotte | 3 | Birnbaum (A), Swiderski, McNeill |
| DC United | 0 | |||
| 3-ago-2022 | Columbus | Crew | 1 | Zelarayan |
| Impact | 2 | Kamara, Waterman | ||
| 3-ago-2022 | Portland | Timbers | 1 | Moreno |
| Nashville | 1 | Bunbury | ||
| 3-ago-2022 | San Jose | Earthquakes | 0 | |
| Inter | 1 | Jean Mota | ||
| 5-ago-2022 | Vancouver | Whitecaps | 2 | Becher, Cavallini |
| Dynamo | 1 | Picault | ||
| 6-ago-2022 | Atlanta | Atlanta United | 2 | Cisneros, Gutman |
| Sounders | 1 | Roldan | ||
| 6-ago-2022 | Charlotte | Charlotte | 2 | Reyna, Swiderski |
| Fire | 3 | Przybylko (2), Navarro | ||
| 6-ago-2022 | Cincinnati | Cincinnati | 3 | Vazquez, Brenner, Barreal |
| Union | 1 | Aaronson | ||
| 6-ago-2022 | Columbus | Crew | 3 | Hernandez, Zelarayan (2) |
| New York City | 2 | Mensah (A), Gabriel Pereira | ||
| 6-ago-2022 | Washington | DC United | 0 | |
| Red Bulls | 0 | |||
| 6-ago-2022 | Montreal | Impact | 2 | Quioto (2, 1P) |
| Inter | 2 | Higuain, Rodriguez | ||
| 6-ago-2022 | Orlando | Orlando City | 0 | |
| Revolution | 3 | Polster, Kaptoum, Kessler | ||
| 6-ago-2022 | Nashville | Nashville | 3 | Mukhtar (P), Bunbury, Zimmermann |
| Toronto | 4 | Osorio (2), Bernardeschi (P), Insigne | ||
| 6-ago-2022 | Kansas City | Sporting | 4 | Thommy, Agada (2), Salloi |
| Galaxy | 2 | Hernandez (2, 1P) | ||
| 6-ago-2022 | Austin | Austin | 3 | Cascante, Driussi (2) |
| Earthquakes | 3 | Kikanovic, Maric, Ebobisse | ||
| 6-ago-2022 | Commerce City | Rapids | 4 | Zardes (3), Rubio |
| Minnesota United | 3 | Danladi, Amarilla, Kallman | ||
| 6-ago-2022 | Sandy | Real Salt Lake | 1 | Cordova |
| Los Angeles | 4 | Arango (2), Acosta, Bale | ||
| 6-ago-2022 | Portland | Timbers | 1 | Loria |
| Dallas | 1 | Chara (A) | ||
| 25ª Semana | ||||
| 13-ago-2022 | Harrison | Red Bulls | 0 | |
| Orlando City | 1 | Torres | ||
| 13-ago-2022 | Cincinnati | Cincinnati | 2 | Vazquez, Brenner |
| Atlanta United | 2 | Almada, Gutman | ||
| 13-ago-2022 | Foxborough | Revolution | 1 | Gil |
| DC United | 0 | |||
| 13-ago-2022 | Chester | Union | 4 | Gazdag, Elliott, Carranza, Burke |
| Fire | 1 | Mueller | ||
| 13-ago-2022 | Toronto | Toronto | 3 | Osorio, Insigne, Bernardeschi |
| Timbers | 1 | Van Rankin | ||
| 13-ago-2022 | Miami | Inter | 3 | Pozuelo (2), Lassiter |
| New York City | 2 | Talles Magno, Thiago Andrade | ||
| 13-ago-2022 | Austin | Austin | 4 | Gallagher, Cascante, Hoesen, Driussi |
| Sporting | 3 | Fontas, Agada, Russell (P) | ||
| 13-ago-2022 | Commerce City | Rapids | 1 | Rubio (P) |
| Crew | 1 | Hernandez | ||
| 13-ago-2022 | Frisco | Dallas | 4 | Ferreira (2), Farfan, Velasco |
| Earthquakes | 1 | Ebobisse | ||
| 13-ago-2022 | Houston | Dynamo | 2 | Ferreira, Steres |
| Impact | 3 | Quioto (P), Johnston, Lappalainen | ||
| 13-ago-2022 | Carson | Galaxy | 5 | Grandsir (2), Hernandez (P), Vazquez, Alvarez |
| Whitecaps | 2 | Gauld, Ricketts | ||
| 13-ago-2022 | Los Angeles | Los Angeles | 5 | Murillo, Cifuentes, Vela, Arango, Walkes (A) |
| Charlotte | 0 | |||
| 14-ago-2022 | Nashville | Nashville | 1 | Mukhtar |
| Minnesota United | 2 | Fragapane, Benitez | ||
| 14-ago-2022 | Seattle | Sounders | 1 | Rusnak |
| Real Salt Lake | 2 | Cordova, Brody | ||
| 26ª Semana | ||||
| 16-ago-2022 | Los Angeles | Los Angeles | 1 | Opoku |
| DC United | 0 | |||
| 17-ago-2022 | Atlanta | Atlanta United | 1 | Martinez |
| Red Bulls | 2 | Morgan, Tolkin | ||
| 17-ago-2022 | Toronto | Toronto | 2 | Bernardeschi (P), Criscito |
| Revolution | 2 | McNamara, Rennicks | ||
| 17-ago-2022 | Bronx | New York City | 1 | Chanot |
| Charlotte | 3 | Swiderski, Bronico, Fuchs (P) | ||
| 17-ago-2022 | Frisco | Dallas | 1 | Ferreira |
| Union | 0 | |||
| 17-ago-2022 | Vancouver | Whitecaps | 2 | Gauld (2) |
| Rapids | 1 | Zardes | ||
| 19-ago-2022 | Carson | Galaxy | 3 | Hernandez, Vazquez, Joveljic (P) |
| Sounders | 3 | Rowe, Ruidiaz, Morris | ||
| 20-ago-2022 | Harrison | Red Bulls | 1 | Klimala (P) |
| Cincinnati | 1 | Miazga | ||
| 20-ago-2022 | Washington | DC United | 0 | |
| Union | 6 | Uhre, Gazdag (P), Carranza (3), Burke | ||
| 20-ago-2022 | Montreal | Impact | 4 | Kamara, Quioto (2), Miljevic (P) |
| Revolution | 0 | |||
| 20-ago-2022 | Saint Paul | Minnesota United | 2 | Reynoso (P), Fragapane |
| Austin | 1 | Driussi (P) | ||
| 20-ago-2022 | Fort Lauderdale | Inter | 2 | Jean Mota, Lassiter |
| Toronto | 1 | Insigne | ||
| 20-ago-2022 | Commerce City | Rapids | 1 | Abubakar |
| Dynamo | 1 | Ferreira | ||
| 20-ago-2022 | Sandy | Real Salt Lake | 1 | Cordova |
| Whitecaps | 1 | Gressel | ||
| 20-ago-2022 | San Jose | Earthquakes | 2 | Kikanovic, Cowell |
| Los Angeles | 1 | Opoku | ||
| 21-ago-2022 | Bridgeview | Fire | 0 | |
| New York City | 2 | Gabriel Pereira, Rodriguez | ||
| 21-ago-2022 | Columbus | Crew | 2 | Hernandez (2) |
| Atlanta United | 2 | Sosa, Purata | ||
| 21-ago-2022 | Charlotte | Charlotte | 1 | Gaines |
| Orlando City | 2 | Kara, Akindele | ||
| 21-ago-2022 | Kansas City | Sporting | 4 | Agada (2), Fontas, Thommy |
| Timbers | 1 | Blanco | ||
| 21-ago-2022 | Nashville | Nashville | 4 | Mukhtar (2), Shaffelburg, Romney |
| Dallas | 0 | |||
| 27ª Semana | ||||
| 26-ago-2022 | Austin | Austin | 4 | Fagundez, Urruti (2), Driussi |
| Los Angeles | 1 | Arango | ||
| 26-ago-2022 | Portland | Timbers | 2 | Asprilla (P), Blanco |
| Sounders | 1 | Gomez | ||
| 27-ago-2022 | Saint Paul | Minnesota United | 2 | Picault (A), Amarilla |
| Dynamo | 1 | Baird | ||
| 27-ago-2022 | Harrison | Red Bulls | 3 | Morgan, Edelman, Clark |
| Inter | 1 | Higuain | ||
| 27-ago-2022 | Cincinnati | Cincinnati | 2 | Vazquez, Miazga |
| Crew | 2 | Etienne, Moreira | ||
| 27-ago-2022 | Chester | Union | 6 | Gazdag (3, 1P), Carranza (P), Burke, Real |
| Rapids | 0 | |||
| 27-ago-2022 | Bridgeview | Fire | 0 | |
| Impact | 2 | Kone, Quioto | ||
| 27-ago-2022 | Charlotte | Charlotte | 0 | |
| Toronto | 2 | Insigne, Bernardeschi | ||
| 27-ago-2022 | Kansas City | Sporting | 1 | Salloi |
| Earthquakes | 0 | |||
| 27-ago-2022 | Frisco | Dallas | 1 | Velasco |
| Real Salt Lake | 1 | Anderson Julio | ||
| 27-ago-2022 | Vancouver | Whitecaps | 0 | |
| Nashville | 3 | Leal, Maher (2) | ||
| 28-ago-2022 | Atlanta | Atlanta United | 3 | Franco, Martinez, Purata |
| DC United | 2 | Morrison, Kamara | ||
| 28-ago-2022 | Orlando | Orlando City | 2 | Junior Urso, Akindele |
| New York City | 1 | Moralez | ||
| 28-ago-2022 | Foxborough | Revolution | 1 | Gil |
| Galaxy | 2 | Aguirre, Hernandez | ||
| 28ª Semana | ||||
| 31-ago-2022 | Chester | Union | 4 | Carranza, Uhre, Gazdag, Harriel |
| Atlanta United | 1 | Gutman | ||
| 31-ago-2022 | Columbus | Crew | 1 | Diaz |
| Inter | 0 | |||
| 31-ago-2022 | Montreal | Impact | 0 | |
| Red Bulls | 1 | Morgan | ||
| 31-ago-2022 | Foxborough | Revolution | 0 | |
| Fire | 0 | |||
| 31-ago-2022 | Toronto | Toronto | 2 | Jimenez, Bernardeschi (P) |
| Galaxy | 2 | Douglas Costa, Puig | ||
| 31-ago-2022 | Bronx | New York City | 1 | Heber |
| DC United | 2 | Kamara, Birnbaum | ||
| 31-ago-2022 | Houston | Dynamo | 2 | Ferreira (P), Dorsey |
| Los Angeles | 1 | Arango | ||
| 31-ago-2022 | Nashville | Nashville | 4 | Mukhtar (3, 1P), Shaffelburg |
| Rapids | 1 | Zardes | ||
| 31-ago-2022 | Orlando | Orlando City | 3 | Torres, Kara (P), Smith |
| Sounders | 2 | Rusnak, Ruidiaz | ||
| 31-ago-2022 | Sandy | Real Salt Lake | 3 | Cordova, Savarino, Julio |
| Minnesota United | 0 | |||
| 31-ago-2022 | Austin | Austin | 1 | Driussi |
| Timbers | 2 | Tuiloma, McGraw | ||
| 3-sep-2022 | Saint Paul | Minnesota United | 0 | |
| Dallas | 3 | Boxall (A), Velasco, Ferreira | ||
| 3-sep-2022 | Columbus | Crew | 0 | |
| Fire | 0 | |||
| 3-sep-2022 | Harrison | Red Bulls | 0 | |
| Union | 2 | Uhre, Gazdag | ||
| 3-sep-2022 | Cincinnati | Cincinnati | 2 | Hagglund, Acosta |
| Charlotte | 0 | |||
| 3-sep-2022 | Nashville | Nashville | 3 | Zimmerman, Mukhtar (2) |
| Austin | 0 | |||
| 4-sep-2022 | Portland | Timbers | 2 | Moreno (P), Asprilla (P) |
| Atlanta United | 1 | Martinez | ||
| 4-sep-2022 | Washington | DC United | 0 | |
| Rapids | 0 | |||
| 4-sep-2022 | Toronto | Toronto | 3 | Bernardeschi (P), Insigne (2) |
| Impact | 4 | Miller, Mihailovic, Kamara, Johnston | ||
| 4-sep-2022 | Foxborough | Revolution | 3 | Bell, Buck, McNamara |
| New York City | 0 | |||
| 4-sep-2022 | Carson | Galaxy | 2 | Hernandez (2, 1P) |
| Sporting | 2 | Russell (P), Hernandez | ||
| 4-sep-2022 | Seattle | Sounders | 2 | Tolo, Montero |
| Dynamo | 1 | Steres | ||
| 4-sep-2022 | San Jose | Earthquakes | 2 | Ebobisse, Monteiro |
| Whitecaps | 0 | |||
| 4-sep-2022 | Los Angeles | Los Angeles | 2 | Hollingshead, Arango |
| Real Salt Lake | 0 | |||
| 29ª Semana | ||||
| 7-sep-2022 | Bronx | New York City | 1 | Gabriel Pereira |
| Cincinnati | 1 | Thiago Martins (A) | ||
| 9-sep-2022 | Montreal | Impact | 2 | Wanyama, Brault-Guillard |
| Crew | 2 | Mensah, Zelarayan | ||
| 10-sep-2022 | Charlotte | Charlotte | 1 | Rios |
| New York City | 0 | |||
| 10-sep-2022 | Nashville | Nashville | 1 | Mukhtar (P) |
| Galaxy | 1 | Puig (P) | ||
| 10-sep-2022 | Harrison | Red Bulls | 2 | Casseres, Morgan (P) |
| Revolution | 1 | McNamara | ||
| 10-sep-2022 | Atlanta | Atlanta | 4 | Purata (3), Almada |
| Toronto | 2 | Akinola, Bernardeschi (P) | ||
| 10-sep-2022 | Cincinnati | Cincinnati | 6 | Barreal, Brenner (3, 1P), Acosta (P), Kubo |
| Earthquakes | 0 | |||
| 10-sep-2022 | Chester | Union | 5 | Joao Moutinho (A), Uhre, Gazdag (P), Bedoya, Elliott |
| Orlando City | 1 | Perea | ||
| 10-sep-2022 | Bridgeview | Fire | 3 | Duran (2), Shaqiri |
| Inter | 1 | Higuain (P) | ||
| 10-sep-2022 | Seattle | Sounders | 3 | Ruidiaz (2), Gabrielsen (A) |
| Austin | 0 | |||
| 10-sep-2022 | Frisco | Dallas | 2 | Ferreira (2) |
| Los Angeles | 1 | Arango | ||
| 10-sep-2022 | Houston | Dynamo | 0 | |
| Sporting | 0 | |||
| 10-sep-2022 | Commerce City | Rapids | 3 | Zardes, Rubio (P), Lewis |
| Whitecaps | 1 | White | ||
| 10-sep-2022 | Sandy | Real Salt Lake | 0 | |
| DC United | 0 | |||
| 11-sep-2022 | Portland | Timbers | 1 | Asprilla |
| Minnesota United | 0 | |||
| 30ª Semana | ||||
| 13-sep-2022 | Montreal | Impact | 3 | Kamara (2), Brault-Guillard |
| Fire | 2 | Shaqiri (2P) | ||
| 13-sep-2022 | Fort Lauderdale | Inter | 2 | Higuain (2) |
| Crew | 1 | Hernandez | ||
| 13-sep-2022 | Saint Paul | Minnesota United | 1 | Kallman |
| Los Angeles | 1 | Vela | ||
| 13-sep-2022 | Houston | Dynamo | 3 | Quintero, Picault (2, 1P) |
| Revolution | 1 | Gil (P) | ||
| 13-sep-2022 | Kansas City | Sporting | 3 | Shelton, Voloder, Salloi |
| DC United | 0 | |||
| 14-sep-2022 | Austin | Austin | 3 | Djitte (3) |
| Real Salt Lake | 0 | |||
| 15-sep-2022 | Commerce City | Rapids | 2 | Rubio, Rosenberry |
| Earthquakes | 1 | Nathan | ||
| 15-sep-2022 | Vancouver | Whitecaps | 3 | Gauld, Vite, Ricketts |
| Galaxy | 0 | |||
| 17-sep-2022 | Bronx | New York City | 2 | Callens, Rodriguez |
| Red Bulls | 0 | |||
| 17-sep-2022 | Atlanta | Atlanta United | 0 | |
| Union | 0 | |||
| 17-sep-2022 | Foxborough | Revolution | 0 | |
| Impact | 1 | Johnston | ||
| 17-sep-2022 | Orlando | Orlando City | 4 | Torres, Kara, MacNaughton (A), Akindele |
| Toronto | 0 | |||
| 17-sep-2022 | Bridgeview | Fire | 2 | Pineda, Duran |
| Charlotte | 3 | Swiderski (2), Nuno Santos | ||
| 17-sep-2022 | Kansas City | Sporting | 4 | Boxall (A), Thommy, Agada (2) |
| Minnesota United | 1 | Garcia | ||
| 17-sep-2022 | Austin | Austin | 1 | Driussi |
| Nashville | 1 | Mukhtar (P) | ||
| 17-sep-2022 | Sandy | Real Salt Lake | 1 | Chang |
| Cincinnati | 2 | Brenner (2) | ||
| 18-sep-2022 | Vancouver | Whitecaps | 2 | Vite, Gressel |
| Sounders | 1 | Bruin | ||
| 18-sep-2022 | Carson | Galaxy | 4 | Brugman (2), Edwards, Hernandez |
| Rapids | 1 | Nicholson | ||
| 18-sep-2022 | San Jose | Earthquakes | 1 | Ebobisse (P) |
| Dallas | 1 | Obrian | ||
| 18-sep-2022 | Columbus | Crew | 1 | Molino |
| Timbers | 1 | Moreno | ||
| 18-sep-2022 | Washington | DC United | 2 | Benteke, Fountas |
| Inter | 3 | Campana (2), Higuain | ||
| 19-sep-2022 | Los Angeles | Los Angeles | 3 | Vela (2P), Hollingshead |
| Dynamo | 1 | Baird | ||
| 31ª Semana | ||||
| 25-sep-2022 | San Jose | Earthquakes | 2 | Espinoza (P), Nathan |
| Galaxy | 3 | Hernandez (2), Brugman | ||
| 28-sep-2022 | Seattle | Sounders | 1 | Montero |
| Cincinnati | 1 | Brenner | ||
| 30-sep-2022 | Toronto | Toronto | 0 | |
| Inter | 1 | Higuain | ||
| 1-oct-2022 | Foxborough | Revolution | 2 | Vrioni (P), Bou |
| Atlanta United | 1 | Martinez | ||
| 1-oct-2022 | Commerce City | Rapids | 1 | Rubio |
| Dallas | 0 | |||
| 1-oct-2022 | Charlotte | Charlotte | 4 | Rios (4, 1P) |
| Union | 0 | |||
| 1-oct-2022 | Cincinnati | Cincinnati | 2 | Acosta, Vazquez |
| Fire | 3 | Duran (2), Gutierrez | ||
| 1-oct-2022 | Columbus | Crew | 2 | Etienne (2) |
| Red Bulls | 1 | Amaya | ||
| 1-oct-2022 | Montreal | Impact | 1 | Pines (A) |
| DC United | 0 | |||
| 2-oct-2022 | San Jose | Earthquakes | 2 | Salinas, Kikanovic |
| Minnesota United | 0 | |||
| 2-oct-2022 | Vancouver | Whitecaps | 2 | Gauld, Cavallini |
| Austin | 0 | |||
| 2-oct-2022 | Carson | Galaxy | 1 | Douglas Costa (P) |
| Real Salt Lake | 1 | Cordova | ||
| 2-oct-2022 | Bronx | New York City | 2 | Callens, Talles Magno |
| Orlando City | 1 | Torres | ||
| 2-oct-2022 | Portland | Timbers | 1 | Asprilla |
| Los Angeles | 2 | Vela, Bouanga | ||
| 2-oct-2022 | Kansas City | Sporting | 1 | Agada |
| Sounders | 0 | |||
| 2-oct-2022 | Nashville | Nashville | 1 | Zimmerman |
| Dynamo | 2 | Ferreira (2, 1P) | ||
| 32ª Semana | ||||
| 5-oct-2022 | Charlotte | Charlotte | 2 | Rios, Shinyashiki |
| Crew | 2 | Zelarayan, Diaz | ||
| 5-oct-2022 | Fort Lauderdale | Inter | 4 | Campana, Higuain (2, 1P), Lassiter |
| Orlando City | 1 | Kara | ||
| 9-oct-2022 | Atlanta | Atlanta United | 1 | Gutman |
| New York City | 2 | Gabriel Pereira, Heber | ||
| 9-oct-2022 | Bridgeview | Fire | 1 | Monis |
| Revolution | 1 | Borrero | ||
| 9-oct-2022 | Washington | DC United | 2 | Morrison, Fletcher |
| Cincinnati | 5 | Acosta, Brenner (3), Vazquez | ||
| 9-oct-2022 | Fort Lauderdale | Inter | 1 | Waterman (A) |
| Impact | 3 | Mihailovic, Lappalainen, Kamara | ||
| 9-oct-2022 | Bronx | Red Bulls | 2 | Manoel (2) |
| Charlotte | 0 | |||
| 9-oct-2022 | Orlando | Orlando City | 2 | Junior Urso, Torres (P) |
| Crew | 1 | Etienne | ||
| 9-oct-2022 | Chester | Union | 4 | Gazdag (3, P), Uhre |
| Toronto | 0 | |||
| 9-oct-2022 | Austin | Austin | 1 | Driussi (P) |
| Rapids | 1 | Rubio | ||
| 9-oct-2022 | Frisco | Dallas | 2 | Lletget, Arrisola |
| Sporting | 1 | Zusi | ||
| 9-oct-2022 | Houston | Dynamo | 1 | Ferreira |
| Galaxy | 3 | Puig, Hernandez, Joveljic | ||
| 9-oct-2022 | Los Angeles | Los Angeles | 0 | |
| Nashville | 1 | Bunbury | ||
| 9-oct-2022 | Saint Paul | Minnesota United | 2 | Fragapane, Gonzalez |
| Whitecaps | 0 | |||
| 9-oct-2022 | Sandy | Real Salt Lake | 3 | Savarino, Mendez, Hidalgo |
| Timbers | 1 | Asprilla | ||
| 9-oct-2022 | Seattle | Sounders | 2 | Lodeiro (2) |
| Earthquakes | 2 | Ebobisse, Cowell | ||
| Playoffs | ||||
| 15-oct-2022 | Harrison | Red Bulls | 1 | Morgan |
| Cincinnati | 2 | Acosta (P), Vazquez | ||
| 15-oct-2022 | Carson | Galaxy | 1 | Araujo |
| Nashville | 0 | |||
| 16-oct-2022 | Austin | Austin | 2(3) | Driussi (2, 1P) |
| Real Salt Lake | 2(1) | Cordova (2, 1P) | ||
| 16-oct-2022 | Montreal | Impact | 2 | Kone, Mihailovic (P) |
| Orlando City | 0 | |||
| 17-oct-2022 | Bronx | New York City | 3 | Gabriel Pereira, Moralez, Heber |
| Inter | 0 | |||
| 17-oct-2022 | Frisco | Dallas | 1(5) | Quignon |
| Minnesota United | 1(4) | Reynoso | ||
| Semifinales de Conferencia | ||||
| 20-oct-2022 | Chester | Union | 1 | Flach |
| Cincinnati | 0 | |||
| 21-oct-2022 | Los Angeles | Los Angeles | 3 | Bouanga (2), Arango |
| Galaxy | 2 | Grandsir, Joveljic | ||
| 23-oct-2022 | Montreal | Impact | 1 | Mihailovic |
| New York City | 3 | Moralez, Heber, Talles Magno (P) | ||
| 23-oct-2022 | Austin | Austin | 2 | Djitte, Driussi |
| Dallas | 1 | Velasco | ||
| Finales de Conferencia | ||||
| 30-oct-2022 | Los Angeles | Los Angeles | 3 | Arango, Urruti (A), Opoku |
| Austin | 0 | |||
| 30-oct-2022 | Chester | Union | 3 | Carranza, Gazdag, Burke |
| New York City | 1 | Moralez | ||
| FINAL MLS | ||||
| 5-nov-2022 | Los Angeles | Los Angeles | 3(3) | Acosta, Murillo, Bale |
| Union | 3(0) | Gazdag, Elliott (2) | ||